PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty acid β-oxidation (FAO). PD-1 promotes FAO of en...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Patsoukis, Nikolaos, Bardhan, Kankana, Chatterjee, Pranam, Sari, Duygu, Liu, Bianling, Bell, Lauren N., Karoly, Edward D., Freeman, Gordon J., Petkova, Victoria, Seth, Pankaj, Li, Lequn, Boussiotis, Vassiliki A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4389235/
https://ncbi.nlm.nih.gov/pubmed/25809635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7692
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