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PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A
The programmed cell death-1 (PD)-1 receptor (CD279) is a potent T cell inhibitor with a critical role in peripheral tolerance, but it can also compromise anti-viral and antitumor T cell responses. The effects of PD-1 on the cell cycle leading to inhibition of T cell expansion are poorly understood....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552912/ https://ncbi.nlm.nih.gov/pubmed/23032366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22135 |
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