Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells

Breast cancer is the most heterogenous cancer type among women across the world. Despite concerted efforts, breast cancer management is still unsatisfactory. Interplay between apoptosis and autophagy is an imperative factor in categorizing therapeutics for cancer treatment. Proscillaridin A (PSD-A),...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Saleem, Muhammad Zubair, Alshwmi, Mohammed, Zhang, He, Din, Syed Riaz Ud, Nisar, Muhammad Azhar, Khan, Muhammad, Alam, Shahid, Alam, Gulzar, Jin, Lingling, Ma, Tonghui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500466/
https://ncbi.nlm.nih.gov/pubmed/33013353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01055
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