ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest

The antiproliferative effect induced by histone deactylase inhibitors (HDACi) is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug. The direct targeting of p21 is...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Scotto, Luigi, Serrano, Xavier J., Zullo, Kelly, Kinahan, Cristina, Deng, Changchun, Sawas, Ahmed, Bates, Susan, O’Connor, Owen A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2020
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500109/
https://ncbi.nlm.nih.gov/pubmed/32973968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27723
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