mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to be identified that confer a druggable vulnerability. Here, we demonstrate...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Gremke, Niklas, Polo, Pierfrancesco, Dort, Aaron, Schneikert, Jean, Elmshäuser, Sabrina, Brehm, Corinna, Klingmüller, Ursula, Schmitt, Anna, Reinhardt, Hans Christian, Timofeev, Oleg, Wanzel, Michael, Stiewe, Thorsten
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499183/
https://ncbi.nlm.nih.gov/pubmed/32943635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18504-7
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