Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis

Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (STAT) family of transcription factors is known to activate critical mediators of cytokine responses, and, among this family, STAT3 is implicated to be a key transcription fa...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Imbaby, Samar, Matsuda, Naoyuki, Tomita, Kengo, Hattori, Kohshi, Palikhe, Sailesh, Yokoo, Hiroki, Hattori, Yuichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498613/
https://ncbi.nlm.nih.gov/pubmed/32943679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72136-x
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