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BRAF(V600E) drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

BRAF(V600E) confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAF(V600E) mutant CRCs. Recent genetic analyses of CRCs indicate that BRAF(V600E) often coexists with...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Reischmann, Nadine, Andrieux, Geoffroy, Griffin, Ricarda, Reinheckel, Thomas, Boerries, Melanie, Brummer, Tilman
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498370/
https://ncbi.nlm.nih.gov/pubmed/32792685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01414-9
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