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BRAF(V600E) drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation
BRAF(V600E) confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAF(V600E) mutant CRCs. Recent genetic analyses of CRCs indicate that BRAF(V600E) often coexists with...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7498370/ https://ncbi.nlm.nih.gov/pubmed/32792685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01414-9 |
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