Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic targets remain largely uncharacteriz...

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Bibliographic Details
Published in:eLife
Main Authors: Mukherjee, Shreyasi, Chaturvedi, Praneet, Rankin, Scott A, Fish, Margaret B, Wlizla, Marcin, Paraiso, Kitt D, MacDonald, Melissa, Chen, Xiaoting, Weirauch, Matthew T, Blitz, Ira L, Cho, Ken WY, Zorn, Aaron M
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498262/
https://ncbi.nlm.nih.gov/pubmed/32894225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58029
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