Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia

BACKGROUND: C-type lectin-like molecule 1 (CLL-1) is highly expressed in acute myeloid leukemia (AML) but is absent in primitive hematopoietic progenitors, making it an attractive target for a chimeric antigen receptor (CAR) T-cell therapy. Here, we optimized our CLL-1 CAR for anti-leukemic activity...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Ataca Atilla, Pinar, McKenna, Mary K, Tashiro, Haruko, Srinivasan, Madhuwanti, Mo, Feiyan, Watanabe, Norihiro, Simons, Brian Wesley, McLean Stevens, Alexandra, Redell, Michele S, Heslop, Helen E, Mamonkin, Maksim, Brenner, Malcolm K, Atilla, Erden
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497527/
https://ncbi.nlm.nih.gov/pubmed/32938629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001229
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