Impact of Manufacturing Procedures on CAR T Cell Functionality

The field of chimeric antigen receptor (CAR) modified T cell therapy has rapidly expanded in the past few decades. As of today, there are six CAR T cell products that have been approved by the FDA: KYMRIAH (tisagenlecleucel, CD19 CAR T cells), YESCARTA (axicabtagene ciloleucel, CD19 CAR T cells), TE...

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Detalhes bibliográficos
Main Authors: Norihiro Watanabe, Feiyan Mo, Mary Kathryn McKenna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Immunology
Assuntos:
CAR T cell
ex vivo expansion
culture media
serum
cytokines
pharmacological inhibitor
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.876339/full
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