Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells

BACKGROUND: Relapsed/refractory B-precursor acute lymphoblastic leukemia (BCP-ALL) remains a major therapeutic challenge in pediatric hematology. Chimeric antigen receptor (CAR) T cells targeting CD19 have shown remarkable initial response rates in BCP-ALL patients, while long-term leukemia control...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Autores principales: Willier, Semjon, Raedler, Johannes, Blaeschke, Franziska, Stenger, Dana, Pazos Escudero, Montserrat, Jurgeleit, Florian, Grünewald, Thomas G P, Binder, Vera, Schmid, Irene, Albert, Michael H, Wolf, Armin, Feuchtinger, Tobias
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2020
Materias:
Case Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497522/
https://ncbi.nlm.nih.gov/pubmed/32938628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001052
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