Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials

[Image: see text] The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium falciparum. We recently validated PfCLK3 as a drug target in malaria that offers prophylactic, transmission blocking, and...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Mahindra, Amit, Janha, Omar, Mapesa, Kopano, Sanchez-Azqueta, Ana, Alam, Mahmood M., Amambua-Ngwa, Alfred, Nwakanma, Davis C., Tobin, Andrew B., Jamieson, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497403/
https://ncbi.nlm.nih.gov/pubmed/32787140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00451
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