Structure‐Based Macrocyclization of Substrate Analogue NS2B‐NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses

A series of cyclic active‐site‐directed inhibitors of the NS2B‐NS3 proteases from Zika (ZIKV), West Nile (WNV), and dengue‐4 (DENV4) viruses has been designed. The most potent compounds contain a reversely incorporated d‐lysine residue in the P1 position. Its side chain is connected to the P2 backbo...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Braun, Niklas J., Quek, Jun P., Huber, Simon, Kouretova, Jenny, Rogge, Dorothee, Lang‐Henkel, Heike, Cheong, Ezekiel Z. K., Chew, Bing L. A., Heine, Andreas, Luo, Dahai, Steinmetzer, Torsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497253/
https://ncbi.nlm.nih.gov/pubmed/32501637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000237
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