Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

West Nile virus (WNV) and Dengue virus (DENV) replication depends on the viral NS2B-NS3 protease and the host enzyme furin, which emerged as potential drug targets. Modification of our previously described WNV protease inhibitors by basic phenylalanine analogs provided compounds with reduced potency...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Kouretova, Jenny, Hammamy, M. Zouhir, Epp, Anton, Hardes, Kornelia, Kallis, Stephanie, Zhang, Linlin, Hilgenfeld, Rolf, Bartenschlager, Ralf, Steinmetzer, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445162/
https://ncbi.nlm.nih.gov/pubmed/28385094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1306521
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