Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Lysine‐specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site‐specific LSD1 inhibition, we developed an enzyme‐prodrug system with the bacterial nitroreductase NfsB (NTR) that wa...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Chembiochem
Päätekijät: Herrlinger, Eva‐Maria, Hau, Mirjam, Redhaber, Desiree Melanie, Greve, Gabriele, Willmann, Dominica, Steimle, Simon, Müller, Michael, Lübbert, Michael, Miething, Christoph Cornelius, Schüle, Roland, Jung, Manfred
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
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Full Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497180/
https://ncbi.nlm.nih.gov/pubmed/32227662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000138
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