Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans‐cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we re...

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Publicado no:Chemistry
Main Authors: de Geus, Mark A. R., Maurits, Elmer, Sarris, Alexi J. C., Hansen, Thomas, Kloet, Max S., Kamphorst, Kiki, ten Hoeve, Wolter, Robillard, Marc S., Pannwitz, Andrea, Bonnet, Sylvestre A., Codée, Jeroen D. C., Filippov, Dmitri V., Overkleeft, Herman S., van Kasteren, Sander I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496853/
https://ncbi.nlm.nih.gov/pubmed/32154603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201905446
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