Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

[Image: see text] Activation of a cytotoxic T-cell is a complex multistep process, and tools to study the molecular events and their dynamics that result in T-cell activation in situ and in vivo are scarce. Here, we report the design and use of conditional epitopes for time-controlled T-cell activat...

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Publicado no:ACS Chem Biol
Main Authors: van der Gracht, Anouk M. F., de Geus, Mark A. R., Camps, Marcel G. M., Ruckwardt, Tracy J., Sarris, Alexi J. C., Bremmers, Jessica, Maurits, Elmer, Pawlak, Joanna B., Posthoorn, Michelle M., Bonger, Kimberly M., Filippov, Dmitri V., Overkleeft, Herman S., Robillard, Marc S., Ossendorp, Ferry, van Kasteren, Sander I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006443/
https://ncbi.nlm.nih.gov/pubmed/29733186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00155
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