Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways

S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases (MTs) catalyse the methylation of a vast array of small metabolites and biomacromolecules. Recently, rare carboxymethylation pathways have been discovered, including carboxymethyltransferase enzymes that utilise a carboxy‐SAM (cxSAM) cofacto...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Herbert, Abigail J., Shepherd, Sarah A., Cronin, Victoria A., Bennett, Matthew R., Sung, Rehana, Micklefield, Jason
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496830/
https://ncbi.nlm.nih.gov/pubmed/32402113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004963
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