Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Dupilumab in Healthy Adult Subjects

Dupilumab is a fully human monoclonal antibody directed against the interleukin (IL)‐4 receptor α subunit (IL‐4Rα) of IL‐4 heterodimeric type I and type II receptors that mediate IL‐4/IL‐13 signaling through this pathway. Blockade of these receptors broadly suppresses type 2 inflammation associated...

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Publicado no:Clin Pharmacol Drug Dev
Main Authors: Li, Zhaoyang, Radin, Allen, Li, Meng, Hamilton, Jennifer D., Kajiwara, Miyuki, Davis, John D., Takahashi, Yoshinori, Hasegawa, Setsuo, Ming, Jeffrey E., DiCioccio, A. Thomas, Li, Yongtao, Kovalenko, Pavel, Lu, Qiang, Ortemann‐Renon, Catherine, Ardeleanu, Marius, Swanson, Brian N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496261/
https://ncbi.nlm.nih.gov/pubmed/32348036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.798
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