Evaluation of Potential Disease‐Mediated Drug–Drug Interaction in Patients With Moderate‐to‐Severe Atopic Dermatitis Receiving Dupilumab

This open‐label drug–drug interaction study assessed whether blockade by dupilumab of interleukin (IL)‐4 and IL‐13 signaling affects the pharmacokinetics of drugs metabolized by cytochrome P450 (CYP450) enzymes. The pharmacokinetics of five CYP450 substrates given orally (midazolam, omeprazole, S‐wa...

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Detaylı Bibliyografya
Yayımlandı:Clin Pharmacol Ther
Asıl Yazarlar: Davis, John D., Bansal, Ashish, Hassman, David, Akinlade, Bolanle, Li, Meng, Li, Zhaoyang, Swanson, Brian, Hamilton, Jennifer D., DiCioccio, A. Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282936/
https://ncbi.nlm.nih.gov/pubmed/29498038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1058
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