RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

BACKGROUND AND AIMS: ARC‐520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV) DNA. APPROACH AND RESULTS: We aimed to evaluate the depth of he...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Hepatology
Hauptverfasser: Yuen, Man‐Fung, Schiefke, Ingolf, Yoon, Jung‐Hwan, Ahn, Sang Hoon, Heo, Jeong, Kim, Ju Hyun, Lik Yuen Chan, Henry, Yoon, Ki Tae, Klinker, Hartwig, Manns, Michael, Petersen, Joerg, Schluep, Thomas, Hamilton, James, Given, Bruce D., Ferrari, Carlo, Lai, Ching‐Lung, Locarnini, Stephen A., Gish, Robert G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496196/
https://ncbi.nlm.nih.gov/pubmed/31654573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31008
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge