RNAi-Based Treatment of Chronically Infected Patients and Chimpanzees Implicates Integrated Hepatitis B Virus DNA as a Source of HBsAg

Chronic hepatitis B virus (HBV) infection is a major health concern worldwide, frequently leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Evidence exists that high viral antigen load may play a role in chronicity. Production of viral proteins is thought to depend on transcrip...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Wooddell, Christine I., Yuen, Man-Fung, Chan, Henry Lik Yuen, Gish, Robert G., Locarnini, Stephen A., Chavez, Deborah, Ferrari, Carlo, Given, Bruce D., Hamilton, James, Kanner, Steven B., Lai, Ching-Lung, Lau, Johnson YN, Schluep, Thomas, Xu, Zhao, Lanford, Robert E., Lewis, David L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830187/
https://ncbi.nlm.nih.gov/pubmed/28954926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan0241
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