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RNAi-Based Treatment of Chronically Infected Patients and Chimpanzees Implicates Integrated Hepatitis B Virus DNA as a Source of HBsAg

Chronic hepatitis B virus (HBV) infection is a major health concern worldwide, frequently leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Evidence exists that high viral antigen load may play a role in chronicity. Production of viral proteins is thought to depend on transcrip...

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מידע ביבליוגרפי
הוצא לאור ב:	Sci Transl Med
Main Authors:	Wooddell, Christine I., Yuen, Man-Fung, Chan, Henry Lik Yuen, Gish, Robert G., Locarnini, Stephen A., Chavez, Deborah, Ferrari, Carlo, Given, Bruce D., Hamilton, James, Kanner, Steven B., Lai, Ching-Lung, Lau, Johnson YN, Schluep, Thomas, Xu, Zhao, Lanford, Robert E., Lewis, David L.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2017
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5830187/ https://ncbi.nlm.nih.gov/pubmed/28954926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan0241
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RNAi-Based Treatment of Chronically Infected Patients and Chimpanzees Implicates Integrated Hepatitis B Virus DNA as a Source of HBsAg

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