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Computationally identifying hot spots in protein-DNA binding interfaces using an ensemble approach

BACKGROUND: Protein-DNA interaction governs a large number of cellular processes, and it can be altered by a small fraction of interface residues, i.e., the so-called hot spots, which account for most of the interface binding free energy. Accurate prediction of hot spots is critical to understand th...

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Bibliografski detalji
Izdano u:BMC Bioinformatics
Glavni autori: Pan, Yuliang, Zhou, Shuigeng, Guan, Jihong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495898/
https://ncbi.nlm.nih.gov/pubmed/32938375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-03675-3
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