Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor

Hypoxia inducible factor (HIFs) signaling contributes to malignant cell behavior in glioblastoma (GBM). We investigated a novel HIF2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma. We focused on analysis of HIF2α e...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Renfrow, Jaclyn J., Soike, Michael H., West, James L., Ramkissoon, Shakti H., Metheny-Barlow, Linda, Mott, Ryan T., Kittel, Carol A., D’Agostino, Ralph B., Tatter, Stephen B., Laxton, Adrian W., Frenkel, Mark B., Hawkins, Gregory A., Herpai, Denise, Sanders, Stephanie, Sarkaria, Jann N., Lesser, Glenn J., Debinski, Waldemar, Strowd, Roy E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495485/
https://ncbi.nlm.nih.gov/pubmed/32938997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72290-2
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