Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

SETD2 catalyzes methylation at lysine 36 of histone H3 and it has many disease connections. We investigated the substrate sequence specificity of SETD2 and identified nine additional peptide and one protein (FBN1) substrates. Our data showed that SETD2 strongly prefers amino acids different from tho...

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Bibliografiset tiedot
Julkaisussa:Commun Biol
Päätekijät: Schuhmacher, Maren Kirstin, Beldar, Serap, Khella, Mina S., Bröhm, Alexander, Ludwig, Jan, Tempel, Wolfram, Weirich, Sara, Min, Jinrong, Jeltsch, Albert
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495481/
https://ncbi.nlm.nih.gov/pubmed/32939018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01223-6
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