Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A

Replication of the genotype 2 hepatitis C virus (HCV) requires hyperphosphorylation of the nonstructural protein NS5A. It has been known that NS5A hyperphosphorylation results from the phosphorylation of a cluster of highly conserved serine residues (S2201, S2208, S2211, and S2214) in a sequential m...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chiang, Cho-Han, Lai, Yen-Ling, Huang, Yu-Ning, Yu, Chun-Chiao, Lu, Christine C., Yu, Guann-Yi, Yu, Ming-Jiun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495366/
https://ncbi.nlm.nih.gov/pubmed/32699091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00420-20
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