IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

Cardiorenal syndrome type 4 (CRS4) is a common complication of chronic kidney disease (CKD), but the pathogenic mechanisms remain elusive. Here we report that morphological and functional changes in myocardial mitochondria are observed in CKD mice, especially decreases in oxidative phosphorylation a...

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Pubblicato in:Nat Commun
Autori principali: Huang, Yinghui, Wang, Shaobo, Zhou, Jie, Liu, Yong, Du, Changhong, Yang, Ke, Bi, Xianjin, Liu, Mingying, Han, Wenhao, Wang, Kailong, Xiong, Jiachuan, Wang, Song, Wang, Yue, Nie, Ling, Liu, Chi, Zhang, Daohai, Gu, Jun, Zeng, Chunyu, Zhao, Jinghong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494935/
https://ncbi.nlm.nih.gov/pubmed/32938919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18519-0
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