Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment

Rationale: The dysfunctional gut-kidney axis forms a vicious circle, which eventually becomes a catalyst for the progression of chronic kidney disease (CKD) and occurrence of related complications. However, the pathogenic factors of CKD-associated intestinal dysfunction and its mechanism remain elus...

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Vydáno v:Theranostics
Hlavní autoři: Huang, Yinghui, Zhou, Jie, Wang, Shaobo, Xiong, Jiachuan, Chen, Yin, Liu, Yong, Xiao, Tangli, Li, Yi, He, Ting, Li, Yan, Bi, Xianjin, Yang, Ke, Han, Wenhao, Qiao, Yu, Yu, Yanli, Zhao, Jinghong
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330852/
https://ncbi.nlm.nih.gov/pubmed/32641998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45455
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