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A Homodimeric Aptamer Variant Generated from Ligand-Guided Selection Activates the T Cell Receptor Cluster of Differentiation 3 Complex

Recently, immunotherapeutic modalities with engineered cells and monoclonal antibodies have been effective in treating several malignancies. Nucleic acid aptamers can serve as alternative molecules to design immunotherapeutic agents with high functional diversity. Here we report a synthetic prototyp...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther Nucleic Acids
Hoofdauteurs: Freage, Lina, Jamal, Deana, Williams, Nicole B., Mallikaratchy, Prabodhika R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494611/
https://ncbi.nlm.nih.gov/pubmed/32920262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.08.016
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