Tuning the Innate Immune Response to Cyclic Dinucleotides Using Atomic Mutagenesis

Cyclic dinucleotides (CDNs) trigger the innate immune response in eukaryotic cells through the STING (stimulator of interferon genes) signalling pathway. To decipher this complex cellular process, a better correlation between structure and downstream function is required. Here we report the design a...

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發表在:Chembiochem
Main Authors: Li, Yao, Fin, Andrea, Rovira, Alexander R., Su, Yichi, Dippel, Andrew B., Valderrama, Jonathan Andrés, Riestra, Angelica M., Nizet, Victor, Hammond, Ming C., Tor, Yitzhak
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494572/
https://ncbi.nlm.nih.gov/pubmed/32346955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000162
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