Tuning the Innate Immune Response to Cyclic Dinucleotides Using Atomic Mutagenesis

Cyclic dinucleotides (CDNs) trigger the innate immune response in eukaryotic cells through the STING (stimulator of interferon genes) signalling pathway. To decipher this complex cellular process, a better correlation between structure and downstream function is required. Here we report the design a...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Li, Yao, Fin, Andrea, Rovira, Alexander R., Su, Yichi, Dippel, Andrew B., Valderrama, Jonathan Andrés, Riestra, Angelica M., Nizet, Victor, Hammond, Ming C., Tor, Yitzhak
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494572/
https://ncbi.nlm.nih.gov/pubmed/32346955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000162
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