Telomere Stress Potentiates STING-Dependent Anti-Tumor Immunity

Telomerase is an attractive target for anti-tumor therapy as it is almost universally expressed in cancer cells. Here we show that treatment with a telomere-targeting drug, 6-thio-2’-deoxyguanosine (6-thio-dG), leads to tumor regression through innate and adaptive immune-dependent responses in synge...

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Udgivet i:Cancer Cell
Main Authors: Mender, Ilgen, Zhang, Anli, Ren, Zhenhua, Han, Chuanhui, Deng, Yafang, Siteni, Silvia, Li, Huiyu, Zhu, Jiankun, Vemula, Aishwarya, Shay, Jerry W., Fu, Yang-Xin
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494563/
https://ncbi.nlm.nih.gov/pubmed/32619407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.05.020
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