Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings

To date, there is no direct evidence of telomerase activity in adult lung epithelial cells, but typical culture conditions only support cell proliferation for 30 to 40 population doublings (PD), a point at which telomeres remain relatively long. Here we report that in in vitro low stress culture con...

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Udgivet i:FASEB J
Main Authors: Peters-Hall, Jennifer R., Min, Jaewon, Tedone, Enzo, Sho, Sei, Siteni, Silvia, Mender, Ilgen, Shay, Jerry W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956733/
https://ncbi.nlm.nih.gov/pubmed/31914653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902376R
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