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A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells

Although telomerase is an almost universal target for cancer therapy, there has been no effective telomerase targeted inhibitor that has progressed to late stage human clinical trials. Recently, we reported that a telomerase-mediated telomere-disrupting compound, 6-thio-2′-deoxyguanosine (6-thio-dG)...

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Vydáno v:Oncoscience
Hlavní autoři: Mender, Ilgen, Gryaznov, Sergei, Shay, Jerry W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580061/
https://ncbi.nlm.nih.gov/pubmed/26425659
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