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Induction of Telomere Dysfunction Mediated By the Telomerase Substrate Precursor 6-Thio-2’-Deoxyguanosine
The relationships between telomerase and telomeres represent attractive targets for new anti-cancer agents. Here, we report that the nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is recognized by telomerase and is incorporated into de novo synthesized telomeres. This results in modified t...
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| Publicado en: | Cancer Discov |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293221/ https://ncbi.nlm.nih.gov/pubmed/25516420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0609 |
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