PRMT5 is upregulated by B cell receptor signaling and forms a positive feedback loop with PI3K/AKT in lymphoma cells

PRMT5, which regulates gene expression by symmetric dimethylation of histones and non-histone target proteins, is overexpressed and plays a pathogenic role in many cancers. In diffuse large B cell lymphoma (DLBCL), the mechanisms of PRMT5 dysregulation and its role in lymphomagenesis remain largely...

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Publicado en:Leukemia
Main Authors: Zhu, Fen, Guo, Hui, Bates, Paul D., Zhang, Shanxiang, Zhang, Hui, Nomie, Krystle J., Li, Yangguang, Lu, Li, Seibold, Kaitlyn R., Wang, Fangyu, Rumball, Ian, Cameron, Hunter, Hoang, Nguyet M., Yang, David T., Xu, Wei, Zhang, Liang, Wang, Michael, Capitini, Christian M., Rui, Lixin
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494157/
https://ncbi.nlm.nih.gov/pubmed/31123343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0489-6
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