NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings

Japanese encephalitis virus (JEV) genotype I (GI) replicates more efficiently than genotype III (GIII) in birds, and this difference is considered to be one of the reasons for the JEV genotype shift. In this study, we utilized duck embryo fibroblasts and domestic ducklings as in vitro and in vivo mo...

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Bibliografische gegevens
Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Li, Chenxi, Di, Di, Huang, Hui, Wang, Xin, Xia, Qiqi, Ma, Xiaochun, Liu, Ke, Li, Beibei, Shao, Donghua, Qiu, Yafeng, Li, Zongjie, Wei, Jianchao, Ma, Zhiyong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494076/
https://ncbi.nlm.nih.gov/pubmed/32881988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008773
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