NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings

Japanese encephalitis virus (JEV) genotype I (GI) replicates more efficiently than genotype III (GIII) in birds, and this difference is considered to be one of the reasons for the JEV genotype shift. In this study, we utilized duck embryo fibroblasts and domestic ducklings as in vitro and in vivo mo...

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Vydáno v:PLoS Pathog
Hlavní autoři: Li, Chenxi, Di, Di, Huang, Hui, Wang, Xin, Xia, Qiqi, Ma, Xiaochun, Liu, Ke, Li, Beibei, Shao, Donghua, Qiu, Yafeng, Li, Zongjie, Wei, Jianchao, Ma, Zhiyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494076/
https://ncbi.nlm.nih.gov/pubmed/32881988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008773
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