Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-tomesenchymal transition

Proximal tubular epithelial cells (PTEC) in the S1 segment of the kidney abundantly express sodium-glucose co-transporters (SGLT) that play a critical role in whole body glucose homeostasis. We recently reported suppression of RECK (Reversion Inducing Cysteine Rich Protein with Kazal Motifs), a memb...

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Опубликовано в: :Cell Signal
Главные авторы: Das, Nitin A., Carpenter, Andrea J., Belenchia, Anthony, Aroor, Annayya R., Noda, Makoto, Siebenlist, Ulrich, Chandrasekar, Bysani, DeMarco, Vincent G.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493965/
https://ncbi.nlm.nih.gov/pubmed/31862399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2019.109506
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