The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion

Chronic inflammation and persistent oxidative stress contribute to the development and progression of vascular proliferative diseases. We hypothesized that the proinflammatory cytokine interleukin (IL)-17A induces oxidative stress and amplifies inflammatory signaling in human aortic smooth muscle ce...

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Publicado en:Cell Signal
Autores principales: Sukhanov, Sergiy, Higashi, Yusuke, Yoshida, Tadashi, Mummidi, Srinivas, Aroor, Annayya R., Russell, Jacob, Bender, Shawn B., DeMarco, Vincent G., Chandrasekar, Bysani
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118186/
https://ncbi.nlm.nih.gov/pubmed/33160017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2020.109825
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