Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing

Axonal degeneration is a key and early pathological feature in traumatic and neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal disintegration by acute axonal degeneration (AAD) occurs within several hours. During AAD, the accumulation of autophagic proteins i...

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發表在:Cell Death Differ
Main Authors: Vahsen, Björn Friedhelm, Ribas, Vinicius Toledo, Sundermeyer, Jonas, Boecker, Alexander, Dambeck, Vivian, Lenz, Christof, Shomroni, Orr, Caldi Gomes, Lucas, Tatenhorst, Lars, Barski, Elisabeth, Roser, Anna-Elisa, Michel, Uwe, Urlaub, Henning, Salinas, Gabriela, Bähr, Mathias, Koch, Jan Christoph, Lingor, Paul
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493890/
https://ncbi.nlm.nih.gov/pubmed/32341448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0543-y
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