PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed different...

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Veröffentlicht in:Vet Res
Hauptverfasser: Bo, Zongyi, Miao, Yurun, Xi, Rui, Zhong, Qiuping, Bao, Chenyi, Chen, Huan, Sun, Liumei, Qian, Yingjuan, Jung, Yong-Sam, Dai, Jianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493860/
https://ncbi.nlm.nih.gov/pubmed/32933581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-020-00843-4
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