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In vitro Activity Assays to Quantitatively Assess the Endogenous Reversible Oxidation State of Protein Tyrosine Phosphatases in Cells
The reversible oxidation of Protein Tyrosine Phosphatases (PTPs) impairs their ability to dephosphorylate substrates in vivo. This transient inactivation of PTPs occurs as their conserved catalytic cysteine residue reacts with cellular oxidants thereby abolishing the ability of this reactive cystein...
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| Veröffentlicht in: | Curr Protoc Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7493824/ https://ncbi.nlm.nih.gov/pubmed/32805074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpch.84 |
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