CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Tumor hypoxia represents a severe microenvironmental stress that is frequently associated with acidosis. Cancer cells respond to these stresses with changes in gene expression that promote survival at least in part through pH regulation and metabolic reprogramming. Hypoxia-induced carbonic anhydrase...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Benej, Martin, Svastova, Eliska, Banova, Radivojka, Kopacek, Juraj, Gibadulinova, Adriana, Kery, Martin, Arena, Simona, Scaloni, Andrea, Vitale, Monica, Zambrano, Nicola, Papandreou, Ioanna, Denko, Nicholas C., Pastorekova, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493625/
https://ncbi.nlm.nih.gov/pubmed/32983978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01462
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