Selection of Macrolide and Non-Macrolide Resistance with Mass Azithromycin Distribution: A Community-Randomized Trial

BACKGROUND: Biannual mass azithromycin distributions to preschool children for 2 years have been shown to reduce childhood mortality in sub-Saharan Africa, but at the cost of amplifying macrolide resistance. Here we investigated the gut resistome of children after 4 additional biannual distributions...

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Udgivet i:N Engl J Med
Main Authors: Doan, Thuy, Worden, Lee, Hinterwirth, Armin, Arzika, Ahmed M., Maliki, Ramatou, Abdou, Amza, Zhong, Lina, Chen, Cindi, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S., Oldenburg, Catherine E., Chow, Eric D., Porco, Travis C., Lipsitch, Marc, Keenan, Jeremy D., Lietman, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: Massachusetts Medical Society 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492079/
https://ncbi.nlm.nih.gov/pubmed/33176084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2002606
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