Selection of Macrolide and Non-Macrolide Resistance with Mass Azithromycin Distribution: A Community-Randomized Trial

BACKGROUND: Biannual mass azithromycin distributions to preschool children for 2 years have been shown to reduce childhood mortality in sub-Saharan Africa, but at the cost of amplifying macrolide resistance. Here we investigated the gut resistome of children after 4 additional biannual distributions...

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Vydáno v:N Engl J Med
Hlavní autoři: Doan, Thuy, Worden, Lee, Hinterwirth, Armin, Arzika, Ahmed M., Maliki, Ramatou, Abdou, Amza, Zhong, Lina, Chen, Cindi, Cook, Catherine, Lebas, Elodie, O’Brien, Kieran S., Oldenburg, Catherine E., Chow, Eric D., Porco, Travis C., Lipsitch, Marc, Keenan, Jeremy D., Lietman, Thomas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Massachusetts Medical Society 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492079/
https://ncbi.nlm.nih.gov/pubmed/33176084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2002606
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