Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

SARS-CoV-2 spike (S) mediates entry into cells and is critical for vaccine development against COVID-19. S is synthesized as a precursor, processed into S1 and S2 by furin proteases, and activated for fusion when human angiotensin-converting enzyme 2 (hACE2) engages the receptor-binding domain (RBD)...

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Publicado no:bioRxiv
Main Authors: Lu, Maolin, Uchil, Pradeep D., Li, Wenwei, Zheng, Desheng, Terry, Daniel S, Gorman, Jason, Shi, Wei, Zhang, Baoshan, Zhou, Tongqing, Ding, Shilei, Gasser, Romain, Prevost, Jeremie, Beaudoin-Bussieres, Guillaume, Anand, Sai Priya, Laumaea, Annemarie, Grover, Jonathan R., Lihong, Liu, Ho, David D, Mascola, John, Finzi, Andres, Kwong, Peter D., Blanchard, Scott C., Mothes, Walther
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491513/
https://ncbi.nlm.nih.gov/pubmed/32935100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.10.286948
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