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Neuroprotective activity of ursodeoxycholic acid in CHMP2B(Intron5) models of frontotemporal dementia

Frontotemporal dementia (FTD) is one of the most prevalent forms of early-onset dementia. It represents part of the FTD-Amyotrophic Lateral Sclerosis (ALS) spectrum, a continuum of genetically and pathologically overlapping disorders. FTD-causing mutations in CHMP2B, a gene encoding a core component...

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Pubblicato in:Neurobiol Dis
Autori principali: West, Ryan J.H., Ugbode, Chris, Fort-Aznar, Laura, Sweeney, Sean T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491204/
https://ncbi.nlm.nih.gov/pubmed/32801000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105047
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