Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity

[Image: see text] Small GTPase protein Rho-kinase (ROCK) plays an important role in the pathogenesis of hypertension. Inhibition of ROCK II brings about the biochemical changes leading to vascular smooth muscles relaxation, finally resulting into potent antihypertensive activity. In the quest for po...

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Publicat a:ACS Med Chem Lett
Autors principals: Kesar, Seema, Paliwal, Sarvesh, Mishra, Pooja, Madan, Kirtika, Chauhan, Monika, Chauhan, Neha, Verma, Kanika, Sharma, Swapnil
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488285/
https://ncbi.nlm.nih.gov/pubmed/32944136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00126
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